User profiles for Kalum Clayton
 | Kalum ClaytonVerified email at kcl.ac.uk Cited by 252 |
[HTML][HTML] Langerhans cells—programmed by the epidermis
Langerhans cells (LCs) reside in the epidermis as a dense network of immune system
sentinels. These cells determine the appropriate adaptive immune response (inflammation or …
sentinels. These cells determine the appropriate adaptive immune response (inflammation or …
[HTML][HTML] Impaired expression of metallothioneins contributes to allergen-induced inflammation in patients with atopic dermatitis
Regulation of cutaneous immunity is severely compromised in inflammatory skin disease.
To investigate the molecular crosstalk underpinning tolerance versus inflammation in atopic …
To investigate the molecular crosstalk underpinning tolerance versus inflammation in atopic …
[HTML][HTML] An IRF1-IRF4 toggle-switch controls tolerogenic and immunogenic transcriptional programming in human Langerhans cells
…, AF Vallejo, S Sirvent, G Porter, K Clayton… - Frontiers in …, 2021 - frontiersin.org
Langerhans cells (LCs) reside in the epidermis as a dense network of immune system
sentinels, coordinating both immunogenic and tolerogenic immune responses. To determine …
sentinels, coordinating both immunogenic and tolerogenic immune responses. To determine …
[HTML][HTML] Genomic programming of IRF4-expressing human Langerhans cells
Langerhans cells (LC) can prime tolerogenic as well as immunogenic responses in skin, but
the genomic states and transcription factors (TF) regulating these context-specific …
the genomic states and transcription factors (TF) regulating these context-specific …
Skin programming of inflammatory responses to Staphylococcus aureus is compartmentalized according to epidermal keratinocyte differentiation status
Background Acute cutaneous inflammation causes microbiome alterations as well as
ultrastructural changes in epidermis stratification. However, the interactions between keratinocyte …
ultrastructural changes in epidermis stratification. However, the interactions between keratinocyte …
[HTML][HTML] Gene expression signatures in tuberculosis have greater overlap with autoimmune diseases than with infectious diseases
Tuberculosis (TB) continues to be depressingly persistent as a global pandemic, killing more
than any other infectious agent (1), and the mechanisms underlying pulmonary pathology …
than any other infectious agent (1), and the mechanisms underlying pulmonary pathology …
Machine learning applied to atopic dermatitis transcriptome reveals distinct therapy‐dependent modification of the keratinocyte immunophenotype
Background Atopic dermatitis (AD) arises from a complex interaction between an impaired
epidermal barrier, environmental exposures, and the infiltration of T helper (Th)1/Th2/Th17/…
epidermal barrier, environmental exposures, and the infiltration of T helper (Th)1/Th2/Th17/…
[HTML][HTML] Transcriptional programming of immunoregulatory responses in human Langerhans cells
Human epidermal Langerhans cells (LCs) maintain immune homeostasis in the skin. To
examine transcriptional programming of human primary LCs during homeostasis, we performed …
examine transcriptional programming of human primary LCs during homeostasis, we performed …
Single cell transcriptomic analysis indentifies Langerhans cells immunocompetency is critical for IDO1-dependent ability to induce tolerogenic T cells
Human epidermal Langerhans cells (LCs) can coordinate both immunogenic and tolerogenic
immune responses, creating an attractive opportunity for immunomodulation strategies. To …
immune responses, creating an attractive opportunity for immunomodulation strategies. To …
TNFα SIGNALLING IN THE CUTANEOUS IMMUNE NETWORK INSTRUCTS LOCAL Th17 ALLERGEN-SPECIFIC INFLAMMATORY RESPONSES IN ATOPIC …
Accurate regulation of cutaneous immunity is fundamental for human health and quality of
life but is severely compromised in inflammatory skin disease. To investigate the molecular …
life but is severely compromised in inflammatory skin disease. To investigate the molecular …