The Bruton’s tyrosine kinase (BTK) inhibitor ibrutinib irreversibly binds BTK at Cys 481 ,
inhibiting its kinase activity and thus blocking transduction of B cell receptor (BCR) signaling. …

Background Gangliosides are glycosphingolipids highly enriched in the brain, with important
roles in cell signaling, cell-to-cell communication, and immunomodulation. Genetic defects …

The regional heterogeneity of neuronal phenotypes is a well-known phenomenon. Whether
or not glia derived from different brain regions are phenotypically and functionally distinct is …

Protein kinase C isozymes are a biologically diverse group of enzymes known to be involved
in a wide variety of cellular processes. They fall into three families (conventional, novel and …

Inflammatory insult to the central nervous system ( CNS ) can lead to development of
depression, and subsequently depression is the most frequent psychiatric comorbidity following …

Gangliosides are sialic acid-containing glycosphingolipids highly enriched in the brain. Located
mainly at the plasma membrane, gangliosides play important roles in signaling and cell-…

For many years the focus of neurochemical and pharmacological studies on schizophrenia
was on dopamine, and that work yielded a great deal of information about the possible …

Negative symptoms are present in over one quarter of patients with schizophrenia and are
detrimental to prognosis, functionality and quality of life. Currently, the treatments for primary …

The development of neuropsychiatric disorders involves an array of different underlying
mechanisms, many of which remain at the level of hypotheses and thus the centre of much …

A new drug discovery strategy by inducing the degradation of oncoproteins through ubiquitin–proteasome
system (UPS) has gained a lot of traction in the last decade (Verma et al. Mol …