Haplotyping germline and cancer genomes with high-throughput linked-read sequencing
…, SM Grimes, S Greer, JY Lee, K Belhocine… - Nature …, 2016 - nature.com
Haplotyping of human chromosomes is a prerequisite for cataloguing the full repertoire of
genetic variation. We present a microfluidics-based, linked-read sequencing technology that …
genetic variation. We present a microfluidics-based, linked-read sequencing technology that …
Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1
P Broz, T Ruby, K Belhocine, DM Bouley, N Kayagaki… - Nature, 2012 - nature.com
Inflammasomes are cytosolic multiprotein complexes assembled by intracellular nucleotide-binding
oligomerization domain (NOD)-like receptors (NLRs) and they initiate innate …
oligomerization domain (NOD)-like receptors (NLRs) and they initiate innate …
Resolving the full spectrum of human genome variation using Linked-Reads
Large-scale population analyses coupled with advances in technology have demonstrated
that the human genome is more diverse than originally thought. To date, this diversity has …
that the human genome is more diverse than originally thought. To date, this diversity has …
Francisella infection triggers activation of the AIM2 inflammasome in murine dendritic cells
K Belhocine, DM Monack - Cellular microbiology, 2012 - Wiley Online Library
The intracellular bacterium Francisella tularensis is the causative agent of tularemia, a
potentially fatal disease. In macrophages, Francisella escapes the initial phagosome and …
potentially fatal disease. In macrophages, Francisella escapes the initial phagosome and …
Conjugation mediates transfer of the Ll. LtrB group II intron between different bacterial species
K Belhocine, I Plante, B Cousineau - Molecular microbiology, 2004 - Wiley Online Library
Some self‐splicing group II introns (ribozymes) are mobile retroelements. These retroelements,
which can insert themselves into cognate intronless alleles or ectopic sites by reverse …
which can insert themselves into cognate intronless alleles or ectopic sites by reverse …
Conjugative Transfer of the Lactococcus lactis Chromosomal Sex Factor Promotes Dissemination of the Ll.LtrB Group II Intron
K Belhocine, KK Yam, B Cousineau - Journal of bacteriology, 2005 - Am Soc Microbiol
The Ll.LtrB group II intron from the low-G+C gram-positive bacterium Lactococcus lactis was
the first bacterial group II intron shown to splice and mobilize in vivo. This retroelement …
the first bacterial group II intron shown to splice and mobilize in vivo. This retroelement …
Trans-splicing of the Ll.LtrB group II intron in Lactococcus lactis
K Belhocine, AB Mak, B Cousineau - Nucleic acids research, 2007 - academic.oup.com
The Ll.LtrB intron from the Gram-positive bacterium Lactococcus lactis is one of the most
studied bacterial group II introns. Ll.LtrB interrupts the relaxase gene of three L. lactis …
studied bacterial group II introns. Ll.LtrB interrupts the relaxase gene of three L. lactis …
Joint single cell DNA-Seq and RNA-Seq of cancer reveals subclonal signatures of genomic instability and gene expression
Sequencing the genomes of individual cancer cells provides the highest resolution of
intratumoral heterogeneity. To enable high throughput single cell DNA-Seq across thousands of …
intratumoral heterogeneity. To enable high throughput single cell DNA-Seq across thousands of …
Trans-splicing versatility of the Ll. LtrB group II intron
K Belhocine, AB Mak, B Cousineau - Rna, 2008 - rnajournal.cshlp.org
Group II introns are found in organelles, bacteria, and archaea. Some harbor an open
reading frame (ORF) with reverse transcriptase, maturase, and occasionally endonuclease …
reading frame (ORF) with reverse transcriptase, maturase, and occasionally endonuclease …
Single-cell multiomics: Simultaneous epigenetic and transcriptional profiling: 10x genomics shares experimental planning and sample preparation tips for the …
K Belhocine, L DeMare, O Habern - Genetic Engineering & …, 2021 - liebertpub.com
Kamila Belhocine, PhD, Laura DeMare, PhD, and Olivia Habern fundamental challenge in
biology is precisely linking gene regulatory networks to the gene expression profiles that …
biology is precisely linking gene regulatory networks to the gene expression profiles that …