Alzheimer's disease (AD) is a neurodegenerative disease often accompanied with disruption
of sleep-wake cycle. The sleep-wake cycle is controlled by mechanisms involving internal …

Objective To evaluate changes in the expression of clock genes and melatonin levels in
patients with idiopathic REM sleep behavior disorder (RBD) as a potential early stage of …

All Arctic visitors have to deal with extreme conditions, including a constant high light intensity
during the summer season or constant darkness during winter. The light/dark cycle serves …

Cells in the human retina must rapidly adapt to constantly changing visual stimuli. This fast
adaptation to varying levels and wavelengths of light helps to regulate circadian rhythms and …

Primary cilia are cellular surface projections enriched in receptors and signaling molecules,
acting as signaling hubs that respond to stimuli. Malfunctions in primary cilia have been …

Decreased levels of Nogo-A-dependent signaling have been shown to affect behavior and
cognitive functions. In Nogo-A knockout and knockdown laboratory rodents, behavioral …

Luciferase reporter assays represent a simple and sensitive experimental system in cell and
molecular biology to study multiple biological processes. However, the application of these …

Retinal microRNA (miRNA) molecules play critical roles in a wide range of processes including
cell proliferation, cell death, and synaptic plasticity. Recently they have been shown to …

Luciferase reporter assays represent a simple and sensitive experimental system in cell and
molecular biology to study multiple biological processes. However, the application of these …

Cirkadiánní systém hraje významnou roli ve fyziologii i patofyziologii člověka. Řídí veškeré
procesy, které se v našem těle opakují s 24 hodinovou periodou. Jedná se o komplexní …