Mutations in presenilins are responsible for the vast majority of early-onset familial Alzheimer's
disease cases. Full-length presenilin structure is composed of nine transmembrane …

Although thousands of breast cancer cells disseminate and home to bone marrow until
primary surgery, usually less than a handful will succeed in establishing manifest metastases …

Aberrant activation of the phosphoinositide 3‐kinase (PI3K)/AKT/mTOR and Ras/mitogen‐activated
protein kinase (MAPK) pathways is a hallmark of hepatocarcinogenesis. In a subset …

Mutations in presenilins ( PS1 and PS2 ) account for the vast majority of early onset familial
A lzheimer's disease cases. Beside the well investigated role of presenilins as the catalytic …

Disrupted intracellular calcium homeostasis is believed to occur early in the cascade of events
leading to Alzheimer's disease (AD) pathology. Particularly familial AD mutations linked to …

Perturbed intracellular store calcium homeostasis is suggested to play a major role in the
pathophysiology of Alzheimer disease (AD). A number of mechanisms have been suggested to …

J. Neurochem. (2011) 119, 1064–1073. Abstract Mutations in presenilins are the major
cause of familial Alzheimer’s disease (FAD), leading to impairments of memory and synaptic …

Background Alzheimer's disease (AD) is characterized by neurodegeneration and changes
in cellular processes, including neurogenesis. Proteolytic processing of the amyloid …

Resected tumors frequently relapse with distant metastasis, despite systemic treatment.
Cellular quiescence has been identified as an important mechanism underlying such drug …

Introduction Circulating tumor and disseminated cancer cells can be detected after surgical
removal of the primary tumor in non-metastatic patients. Despite being considered the prime …