Ferroptosis is a type of regulated cell death driven by the iron-dependent accumulation of
oxidized polyunsaturated fatty acid-containing phospholipids. There is no reliable way to …

Ferroptosis is a regulated form of cell death that occurs when phospholipids with polyunsaturated
fatty acyl tails are oxidized in an iron-dependent manner. Research in recent years has …

Cell death is critical for the development and homeostasis of almost all multicellular organisms.
Moreover, its dysregulation leads to diverse disease states. Historically, apoptosis was …

Ferroptosis is an iron-dependent form of regulated cell death linking iron, lipid, and glutathione
levels to degenerative processes and tumor suppression. By performing a genome-wide …

The let-7 miRNA and its target gene Lin-28 interact in a regulatory circuit controlling pluripotency.
We investigated an additional let-7 target, mLin41 (mouse homologue of lin-41), as a …

Proteolytic activity of the mucosa-associated lymphoid tissue lymphoma translocation protein-1
(MALT1) paracaspase is required for survival of the activated B cell subtype of diffuse …

Parkin, a RING-between-RING-type E3 ubiquitin ligase associated with Parkinson's disease,
has a wide neuroprotective activity, preventing cell death in various stress paradigms. We …

The IκB kinase (IKK) complex acts as a gatekeeper of canonical NF-κB signaling in response
to upstream stimulation. IKK activation requires sensing of ubiquitin chains by the essential …

Highlights • Complex phenotypic imaging assays aim at mimicking the biology of interest. •
Cellular profiling in high-content assays improve description of compound actions. • …

Totipotent cells hold enormous potential for regenerative medicine. Thus, the development
of cellular models recapitulating totipotent-like features is of paramount importance. Cells …