We present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of
juvenile rat. The reconstruction uses cellular and synaptic organizing principles to …

Many biological systems consist of branching structures that exhibit a wide variety of shapes.
Our understanding of their systematic roles is hampered from the start by the lack of a …

We have established a multi-constraint, data-driven process to digitally reconstruct, and
simulate prototypical neocortical microcircuitry, using sparse experimental data. We applied this …

Environmental cues influence the highly dynamic morphology of microglia. Strategies to
characterize these changes usually involve user-selected morphometric features, which …

Synaptic transmission constitutes the primary mode of communication between neurons. It
is extensively studied in rodent but not human neocortex. We characterized synaptic …

There have been few quantitative characterizations of the morphological, biophysical, and
cable properties of neurons in the human neocortex. We employed feature-based statistical …

A consensus on the number of morphologically different types of pyramidal cells (PCs) in the
neocortex has not yet been reached, despite over a century of anatomical studies, due to …

Astrocytes connect the vasculature to neurons mediating the supply of nutrients and
biochemicals. They are involved in a growing number of physiological and pathophysiological …

Methods of topological data analysis have been successfully applied in a wide range of fields
to provide useful summaries of the structure of complex data sets in terms of topological …

The function of the neocortex is fundamentally determined by its repeating microcircuit motif,
but also by its rich, hierarchical, interregional structure with a highly specific laminar …