The Ku70/80 heterodimer is a critical component of the non‐homologous end‐joining (NHEJ)
pathway and of the telomere cap in yeast and mammals. We report the molecular …

Loss of telomere function in metazoans results in catastrophic damage to the genome, cell
cycle arrest, and apoptosis. Here we show that the mustard weed Arabidopsis thaliana can …

The Mre11/Rad50/Nbs1 complex is involved in many aspects of chromosome metabolism.
Aberrant function of the complex is associated with defects in the DNA checkpoint, double-…

Telomerase is an essential enzyme that maintains telomeres on eukaryotic chromosomes.
In mammals, telomerase is required for the lifelong proliferative capacity of normal …

End‐to‐end fusion of critically shortened telomeres in higher eucaryotes is presumed to be
mediated by nonhomologous end‐joining (NHEJ). Here we describe two PCR‐based …

Chromosome termini form a specialized type of heterochromatin that is important for
chromosome stability. The recent discovery of telomeric RNA transcripts in yeast and vertebrates …

Telomere lengths and telomerase activity were studied during the development of a model
dioecious plant, Melandrium album (syn Silene latifolia). Telomeric DNA consisted of …

Nonsense-mediated mRNA decay (NMD) is a conserved eukaryotic RNA surveillance
mechanism that degrades aberrant mRNAs. NMD impairment in Arabidopsis is linked to …

Telomeres in mammals and plants are protected by the terminal t loop structure, the formation
of which parallels the first steps of intrachromatid homologous recombination (HR). Under …

Nonsense-mediated RNA decay (NMD) is an evolutionarily conserved RNA quality control
mechanism that eliminates transcripts containing nonsense mutations. NMD has also been …