User profiles for Karen J. Gonzalez
Karen J. GonzalezPostdoctoral Research Associate, Washington University in St. Louis Verified email at wustl.edu Cited by 30 |
[HTML][HTML] A general computational design strategy for stabilizing viral class I fusion proteins
Many pathogenic viruses rely on class I fusion proteins to fuse their viral membrane with the
host cell membrane. To drive the fusion process, class I fusion proteins undergo an …
host cell membrane. To drive the fusion process, class I fusion proteins undergo an …
[HTML][HTML] Targeting viral surface proteins through structure-based design
The emergence of novel viral infections of zoonotic origin and mutations of existing human
pathogenic viruses represent a serious concern for public health. It warrants the …
pathogenic viruses represent a serious concern for public health. It warrants the …
Skp1 dimerization conceals its F-box protein binding site
HW Kim, A Eletsky, KJ Gonzalez, H Van Der Wel… - Biochemistry, 2020 - ACS Publications
Skp1 is an adapter that links F-box proteins to cullin-1 in the Skp1/cullin-1/F-box (SCF)
protein family of E3 ubiquitin ligases that targets specific proteins for polyubiquitination and …
protein family of E3 ubiquitin ligases that targets specific proteins for polyubiquitination and …
In silico identification of potential inhibitors against human 2'-5'-oligoadenylate synthetase (OAS) proteins
KJ Gonzalez, DM Moncada-Giraldo… - … Biology and Chemistry, 2020 - Elsevier
As part of the type I IFN signaling, the 2′-5′- oligoadenylate synthetase (OAS) proteins
have been involved in the progression of several non-viral diseases. Notably, OAS has been …
have been involved in the progression of several non-viral diseases. Notably, OAS has been …
Systematic computer-aided disulfide design as a general strategy to stabilize prefusion class I fusion proteins
KJ Gonzalez, K Yim, JC Blanco, MS Boukhvalova… - bioRxiv, 2024 - biorxiv.org
Numerous enveloped viruses, such as coronaviruses, influenza, and respiratory syncytial
virus (RSV), utilize class I fusion proteins for cell entry. During this process, the proteins …
virus (RSV), utilize class I fusion proteins for cell entry. During this process, the proteins …
[HTML][HTML] Decreased vaccine protection of egg-based influenza vaccine in the elderly and nonhemagglutinin-focused immunity
KJ Gonzalez, EM Strauch - The Journal of Clinical …, 2021 - Am Soc Clin Investig
Severe influenza illness or death is a serious concern among the elderly population despite
vaccination. To investigate how the adaptive immune response after vaccination varies with …
vaccination. To investigate how the adaptive immune response after vaccination varies with …
A general computational design strategy for stabilizing viral class I fusion proteins (preprint)
Many pathogenic viruses, including influenza virus, Ebola virus, coronaviruses, and
Pneumoviruses, rely on class I fusion proteins to fuse viral and cellular membranes. To drive the …
Pneumoviruses, rely on class I fusion proteins to fuse viral and cellular membranes. To drive the …
Computational Vaccine Design of Class I Fusion Proteins
KJ Gonzalez - esploro.libs.uga.edu
Class I fusion protein Consensus-based sequence design Protein stabilization Respiratory
viruses Structure-based protein design Vaccine development Molecular biology
viruses Structure-based protein design Vaccine development Molecular biology
Mats of the nonnative macroalga, Gracilaria vermiculophylla, alter net denitrification rates and nutrient fluxes on intertidal mudflats
We hypothesized that mats of a nonnative macroalga, Gracilaria vermiculophylla, which is
often found incorporated several centimeters into intertidal mudflat sediments, would increase …
often found incorporated several centimeters into intertidal mudflat sediments, would increase …
Non-native macroalga may increase concentrations of Vibrio bacteria on intertidal mudflats
We investigated whether the proliferation of a non-native macroalga, Gracilaria vermiculophylla,
within the mid-Atlantic coast region, USA, could be related to concentrations of Vibrio …
within the mid-Atlantic coast region, USA, could be related to concentrations of Vibrio …