Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex
…, JP Julien, KL Saye-Francisco… - Proceedings of the …, 2014 - National Acad Sciences
Broadly neutralizing antibodies (bnAbs) targeting the trimer apex of HIV envelope are favored
candidates for vaccine design and immunotherapy because of their great neutralization …
candidates for vaccine design and immunotherapy because of their great neutralization …
[PDF][PDF] Sequential immunization elicits broadly neutralizing anti-HIV-1 antibodies in Ig knockin mice
…, KH Yao, E Georgeson, KL Saye-Francisco… - Cell, 2016 - cell.com
A vaccine that elicits broadly neutralizing antibodies (bNAbs) against HIV-1 is likely to be
protective, but this has not been achieved. To explore immunization regimens that might elicit …
protective, but this has not been achieved. To explore immunization regimens that might elicit …
[PDF][PDF] Tailored immunogens direct affinity maturation toward HIV neutralizing antibodies
…, KM Le, A Ramos, M Jones, KL Saye-Francisco… - Cell, 2016 - cell.com
Induction of broadly neutralizing antibodies (bnAbs) is a primary goal of HIV vaccine
development. VRC01-class bnAbs are important vaccine leads because their precursor B cells …
development. VRC01-class bnAbs are important vaccine leads because their precursor B cells …
Promiscuous glycan site recognition by antibodies to the high-mannose patch of gp120 broadens neutralization of HIV
…, B Briney, KM Le, KL Saye-Francisco… - Science translational …, 2014 - science.org
Broadly neutralizing monoclonal antibodies (bnmAbs) that target the high-mannose patch
centered around the glycan at position 332 on HIV Env are promising vaccine leads and …
centered around the glycan at position 332 on HIV Env are promising vaccine leads and …
Rapid elicitation of broadly neutralizing antibodies to HIV by immunization in cows
D Sok, KM Le, M Vadnais, KL Saye-Francisco… - Nature, 2017 - nature.com
No immunogen to date has reliably elicited broadly neutralizing antibodies to HIV in humans
or animal models. Advances in the design of immunogens that antigenically mimic the HIV …
or animal models. Advances in the design of immunogens that antigenically mimic the HIV …
[PDF][PDF] A prominent site of antibody vulnerability on HIV envelope incorporates a motif associated with CCR5 binding and its camouflaging glycans
The dense patch of high-mannose-type glycans surrounding the N332 glycan on the HIV
envelope glycoprotein (Env) is targeted by multiple broadly neutralizing antibodies (bnAbs). …
envelope glycoprotein (Env) is targeted by multiple broadly neutralizing antibodies (bnAbs). …
[HTML][HTML] Minimally mutated HIV-1 broadly neutralizing antibodies to guide reductionist vaccine design
…, S Spencer, M Pauthner, KL Saye-Francisco… - PLoS …, 2016 - journals.plos.org
An optimal HIV vaccine should induce broadly neutralizing antibodies (bnAbs) that neutralize
diverse viral strains and subtypes. However, potent bnAbs develop in only a small fraction …
diverse viral strains and subtypes. However, potent bnAbs develop in only a small fraction …
HIV-1 vaccine design through minimizing envelope metastability
Overcoming envelope metastability is crucial to trimer-based HIV-1 vaccine design. Here, we
present a coherent vaccine strategy by minimizing metastability. For 10 strains across five …
present a coherent vaccine strategy by minimizing metastability. For 10 strains across five …
[HTML][HTML] Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design
…, O Kalyuzhniy, D Sok, KL Saye-Francisco… - PLoS …, 2017 - journals.plos.org
Among broadly neutralizing antibodies to HIV, 10E8 exhibits greater neutralizing breadth
than most. Consequently, this antibody is the focus of prophylactic/therapeutic development. …
than most. Consequently, this antibody is the focus of prophylactic/therapeutic development. …
[PDF][PDF] Rapid and focused maturation of a VRC01-class HIV broadly neutralizing antibody lineage involves both binding and accommodation of the N276-glycan
The VH1-2 restricted VRC01-class of antibodies targeting the HIV envelope CD4 binding
site are a major focus of HIV vaccine strategies. However, a detailed analysis of VRC01-class …
site are a major focus of HIV vaccine strategies. However, a detailed analysis of VRC01-class …