User profiles for Karen N. Barnard
Karen N BarnardFred Hutchinson Cancer Research Center Verified email at fredhutch.org Cited by 406 |
[HTML][HTML] Effects of sialic acid modifications on virus binding and infection
Sialic acids (Sias) are abundantly displayed on the surfaces of vertebrate cells, and particularly
on all mucosal surfaces. Sias interact with microbes of many types, and are the targets of …
on all mucosal surfaces. Sias interact with microbes of many types, and are the targets of …
Distribution of O-acetylated sialic acids among target host tissues for influenza virus
BR Wasik, KN Barnard, RJ Ossiboff, Z Khedri, KH Feng… - Msphere, 2017 - Am Soc Microbiol
Sialic acids (Sias) are important glycans displayed on the cells and tissues of many different
animals and are frequent targets for binding and modification by pathogens, including …
animals and are frequent targets for binding and modification by pathogens, including …
Expression of 9-O- and 7,9-O-Acetyl Modified Sialic Acid in Cells and Their Effects on Influenza Viruses
Sialic acids (Sia) are widely displayed on the surfaces of cells and tissues. Sia come in a
variety of chemically modified forms, including those with acetyl modifications at the C-7, C-8, …
variety of chemically modified forms, including those with acetyl modifications at the C-7, C-8, …
Deacetylated sialic acids modulates immune mediated cytotoxicity via the sialic acid-Siglec pathway
S Grabenstein, KN Barnard, M Anim, A Armoo… - …, 2021 - academic.oup.com
Cancers utilize glycans to evade the immune system via the Sialic acid (Sia)-Siglec (Sialic-acid-binding
immunoglobulin-like lectins) pathway. Specifically, atypical structural forms of …
immunoglobulin-like lectins) pathway. Specifically, atypical structural forms of …
Modified sialic acids on mucus and erythrocytes inhibit influenza A virus hemagglutinin and neuraminidase functions
KN Barnard, BK Alford-Lawrence, DW Buchholz… - Journal of …, 2020 - Am Soc Microbiol
Sialic acids (Sia) are the primary receptors for influenza viruses and are widely displayed
on cell surfaces and in secreted mucus. Sia may be present in variant forms that include O-…
on cell surfaces and in secreted mucus. Sia may be present in variant forms that include O-…
[HTML][HTML] The role of 9-O-acetylated glycan receptor moieties in the typhoid toxin binding and intoxication
Typhoid toxin is an A 2 B 5 toxin secreted from Salmonella Typhi-infected cells during
human infection and is suggested to contribute to typhoid disease progression and the …
human infection and is suggested to contribute to typhoid disease progression and the …
[HTML][HTML] Recognition of specific sialoglycan structures by oral streptococci impacts the severity of endocardial infection
Streptococcus gordonii and Streptococcus sanguinis are primary colonizers of the tooth
surface. Although generally non-pathogenic in the oral environment, they are a frequent cause …
surface. Although generally non-pathogenic in the oral environment, they are a frequent cause …
[HTML][HTML] Influenza D binding properties vary amongst the two major virus clades and wildlife species
N Nemanichvili, AJ Berends, I Tomris, KN Barnard… - Veterinary …, 2022 - Elsevier
The influenza D virus (IDV) uses a trimeric hemagglutinin-esterase fusion protein (HEF) for
attachment to 9-O-acetylated sialic acid receptors on the cell surface of host species. So far …
attachment to 9-O-acetylated sialic acid receptors on the cell surface of host species. So far …
Influenza viruses in mice: deep sequencing analysis of serial passage and effects of sialic acid structural variation
Influenza A viruses have regularly jumped to new host species to cause epidemics or pandemics,
an evolutionary process that involves variation in the viral traits necessary to overcome …
an evolutionary process that involves variation in the viral traits necessary to overcome …
Sequence dynamics of three influenza A virus strains grown in different MDCK cell lines, including those expressing different sialic acid receptors
KN Barnard, BR Wasik, BK Alford… - Journal of …, 2021 - academic.oup.com
Viruses are often cultured in cell lines for research and vaccine development, and those
often differ from the natural hosts or tissues. Cell lines can also differ in the presence of virus …
often differ from the natural hosts or tissues. Cell lines can also differ in the presence of virus …