Little is known of the molecular basis of normal auditory function. In contrast to the visual or
olfactory senses, in which reasonable amounts of sensory tissue can be gathered, the …

Two large-scale phenotyping efforts, the European Mouse Disease Clinic (EUMODIC) and
the Wellcome Trust Sanger Institute Mouse Genetics Project (SANGER-MGP), started during …

USHER syndrome represents the association of a hearing impairment with retinitis
pigmentosa 1 and is the most frequent cause of deaf–blindness in humans. It is inherited as an …

As the human genome project approaches completion, the challenge for mammalian geneticists
is to develop approaches for the systematic determination of mammalian gene function. …

We identified two novel mouse mutants with abnormal head-shaking behavior and neural
tube defects during the course of independent ENU mutagenesis experiments. The …

… & Steel, КРТНе development and interpretation of the summating potential … , P J. DNA
tearrangements locatea over 100 ко 5 оi the Sfeel (S)-софіпg region in Steel-panda and Steel-…

MicroRNAs (miRNAs) bind to complementary sites in their target mRNAs to mediate post-transcriptional
repression 1 , 2 , with the specificity of target recognition being crucially …

Sensory hair cells and their associated non-sensory supporting cells in the inner ear are
fundamental for hearing and balance. They arise from a common progenitor 1 , but little is …

Genetic hearing impairment affects around 1 in every 2,000 births 1 . The bulk (approximately
70%) of genetic deafness is non-syndromic, in which hearing impairment is not associated …

Mutations in whole organisms are powerful ways of interrogating gene function in a realistic
context. We describe a program, the Sanger Institute Mouse Genetics Project, that provides …