User profiles for Karen S Messer

Karen Messer

Professor, Family and Preventive Medicine, School of Medicine, University of California San …
Verified email at ucsd.edu
Cited by 13582

PI3Kγ is a molecular switch that controls immune suppression

…, KS Messer, N Ralainirina, H Li, CJ Leem, S Gorjestani… - Nature, 2016 - nature.com
Macrophages play critical, but opposite, roles in acute and chronic inflammation and cancer
1 , 2 , 3 , 4 , 5 . In response to pathogens or injury, inflammatory macrophages express …

Intermittent and light daily smoking across racial/ethnic groups in the United States

…, MM White, RA Grana, KS Messer - Nicotine & Tobacco …, 2009 - academic.oup.com
Introduction: Limited research exists examining the prevalence of intermittent (nondaily) and
light daily (1–5 cigarettes/day) smoking across racial/ethnic groups in the United States …

[HTML][HTML] Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer

…, T Hosoya, MM Kaneda, JA Varner, M Pu, KS Messer… - JCI insight, 2017 - ncbi.nlm.nih.gov
Checkpoint inhibitors have demonstrated efficacy in patients with recurrent or metastatic
head and neck squamous cell carcinoma (HNSCC). However, the majority of patients do not …

Integrated analysis of exosomal protein biomarkers on alternating current electrokinetic chips enables rapid detection of pancreatic cancer in patient blood

JM Lewis, AD Vyas, Y Qiu, KS Messer, R White… - ACS …, 2018 - ACS Publications
Pancreatic ductal adenocarcinoma (PDAC) typically has nonspecific symptoms and is often
found too late to treat. Because diagnosis of PDAC involves complex, invasive, and …

Paternally inherited cis-regulatory structural variants are associated with autism

…, C Toma, B Cormand, I Rueda, S Guijarro, KS Messer… - Science, 2018 - science.org
The genetic basis of autism spectrum disorder (ASD) is known to consist of contributions from
de novo mutations in variant-intolerant genes. We hypothesize that rare inherited structural …

Improving patient quality of life with feedback to physicians about functional status

…, DW Cope, PA Barrett, SH Hirsch, KS Messer… - Journal of general …, 1995 - Springer
… In a similar 1986 study 4 we provided university clinical faculty physicians in office practice
s and housestaff 6 at a university primary care clinic with only patient functional status …

[HTML][HTML] A comprehensive safety trial of chimeric antibody 14.18 with GM-CSF, IL-2, and isotretinoin in high-risk neuroblastoma patients following myeloablative …

…, SC Tenney, M Smith, KS Messer… - Frontiers in …, 2018 - frontiersin.org
Purpose A phase 3 randomized study (COG ANBL0032) demonstrated significantly
improved outcome by adding immunotherapy with ch14.18 antibody to isotretinoin as post-…

[HTML][HTML] Multipotent luminal mammary cancer stem cells model tumor heterogeneity

L Bao, RD Cardiff, P Steinbach, KS Messer… - Breast Cancer …, 2015 - Springer
Introduction The diversity of human breast cancer subtypes has led to the hypothesis that
breast cancer is actually a number of different diseases arising from cells at various stages of …

Fluorescence-guided surgery allows for more complete resection of pancreatic cancer, resulting in longer disease-free survival compared with standard surgery in …

…, CR Hardamon, CS Snyder, M Pu, KS Messer… - Journal of the American …, 2012 - Elsevier
BACKGROUND: Negative surgical margins are vital to achieve cure and prolong survival in
patients with pancreatic cancer. We inquired if fluorescence-guided surgery (FGS) could …

Correction: corrigendum: PI3Kγ is a molecular switch that controls immune suppression

…, KS Messer, N Ralainirina, H Li, CJ Leem, S Gorjestani… - Nature, 2017 - ideas.repec.org
Karen McGovern … Kaneda & Karen S. Messer & Natacha Ralainirina & Hongying Li &
Christopher J. Leem & Sara Gorjestani & Gyunghwi Woo & Abraham V. Nguyen & Camila C. …