Preimplantation genetic diagnosis (PGD) was introduced at the beginning of the 1990s as
an alternative to prenatal diagnosis, to prevent termination of pregnancy in couples with a …

Globally, IVF patients are routinely offered and charged for a selection of adjunct treatments
and tests or ‘add-ons’ that they are told may improve their chance of a live birth, despite …

STUDY QUESTION We wanted to probe the opinions and current practices on preimplantation
genetic screening (PGS), and more specifically on PGS in its newest form: PGS 2.0? …

Multiple displacement amplification (MDA) is a recently described method of whole-genome
amplification (WGA) that has proven efficient in the amplification of small amounts of DNA, …

Cultured human embryonic stem (hES) cells have a known predisposition to aneuploidy of
chromosomes 12, 17 and X. We studied 17 hES cell lines by array-based comparative …

BACKGROUND: Human embryonic stem (hES) cells are pluripotent cells usually derived
from the inner cell mass (ICM) of blastocysts. Because of their ability to differentiate into all …

The scarcity of genomic DNA can be a limiting factor in some fields of genetic research. One
of the methods developed to overcome this difficulty is whole genome amplification (WGA). …

STUDY QUESTION What are the aneuploidy rates and incidence of mosaicism in good-quality
human preimplantation embryos. SUMMARY ANSWER High-level mosaicism and …

BACKGROUND Preimplantation genetic diagnosis or screening (PGD, PGS) involves embryo
biopsy on Day 3. Opting for one- or two-cell biopsy is a balance between the lowest risk …

Genomic imbalances are a major cause of constitutional and acquired disorders. Therefore,
aneuploidy screening has become the cornerstone of preimplantation, prenatal and …