The tumour-suppressor p53 is a short-lived protein that is maintained at low, often undetectable,
levels in normal cells. Stabilization of the protein in response to an activating signal, …

The p53 tumor-suppressor protein prevents cancer development through various mechanisms,
including the induction of cell-cycle arrest, apoptosis, and the maintenance of genome …

Beneath the complexity and idiopathy of every cancer lies a limited number of 'mission critical'
events that have propelled the tumour cell and its progeny into uncontrolled expansion …

The p53 tumor-suppressor protein functions as a transcriptional activator, and several p53-inducible
genes that play a role in the induction of apoptosis in response to p53 have been …

Many different types of cancer show a high incidence of TP53 mutations, leading to the
expression of mutant p53 proteins. There is growing evidence that these mutant p53s have both …

The two distinct proteins encoded by the CDKN2A locus are specified by translating the
common second exon in alternative reading frames. The product of the α transcript, p16 INK4a, …

Compared with many normal tissues, cancer cells are highly sensitized to apoptotic signals,
and survive only because they have acquired lesions — such as loss of p53 — that prevent …

From among the cast of thousands that appear to play a role in the regulation of programmed
cell death, p53 has emerged as one of the leading stars. p53 is a protein of many talents, …

Although metabolic alterations have been observed in cancer for almost a century, only
recently have the mechanisms underlying these changes been identified and the importance of …

Loss of the p53 tumor suppressor pathway contributes to the development of most human
cancers. p53 is a nuclear protein that functions as a regulator of transcription. Significant …