The components of the replisome that preserve genomic stability by controlling the progression
of eukaryotic DNA replication forks are poorly understood. Here, we show that the GINS (…

Little is known about the DNA helicases required for the elongation phase of eukaryotic
chromosome replication. Minichromosome maintenance (MCM) protein complexes have DNA …

The accurate and complete replication of genomic DNA is essential for all life. In eukaryotic
cells, the assembly of the multi-enzyme replisomes that perform replication is divided into …

Deubiquitinating enzymes (DUBs) remove ubiquitin (Ub) from Ub-conjugated substrates to
regulate the functional outcome of ubiquitylation. Here we report the discovery of a new …

Replisome assembly at eukaryotic replication forks connects the DNA helicase to DNA
polymerases and many other factors. The helicase binds the leading-strand polymerase directly, …

Introduction Chromosome replication is initiated by a universal mechanism in eukaryotic
cells. This mechanism entails the assembly and activation at replication origins of the DNA …

Chromosome replication occurs precisely once during the cell cycle of almost all eukaryotic
cells, and is a highly complex process that is still understood relatively poorly. Two …

The replication of DNA is a fundamental step in the cell cycle, which must be coordinated
with cell division to ensure that the daughter cells have the same ploidy as the parental cell. …

Eukaryotic cells regulate the progression and integrity of DNA replication forks to maintain
genomic stability and couple DNA synthesis to other processes. The budding yeast proteins …

The eukaryotic replisome is a crucial determinant of genome stability, but its structure is still
poorly understood. We found previously that many regulatory proteins assemble around the …