Cells actively sense and process mechanical information that is provided by the extracellular
environment to make decisions about growth, motility and differentiation. It is important to …

Collagen forms fibrous networks that reinforce tissues and provide an extracellular matrix
for cells. These networks exhibit remarkable strain-stiffening properties that tailor the …

The tumor micro-environment often contains stiff and irregular-bundled collagen fibers that
are used by tumor cells to disseminate. It is still unclear how and to what extent, extracellular …

During wound healing and angiogenesis, fibrin serves as a provisional extracellular matrix.
We use a model system of fibroblasts embedded in fibrin gels to study how cell-mediated …

Bundles of polymer filaments are responsible for the rich and unique mechanical behaviors
of many biomaterials, including cells and extracellular matrices. In fibrin biopolymers, whose …

Fibrin is a plasma protein with a central role in blood clotting and wound repair. Upon vascular
injury, fibrin forms resilient fibrillar networks (clots) via a multistep self-assembly process, …

CRYAB (αB-crystallin) is expressed in many tissues and yet the R120G mutation in CRYAB
causes tissue-specific pathologies, namely cardiomyopathy and cataract. Here, we present …

Fibrin is the major extracellular component of blood clots and a proteinaceous hydrogel
used as a versatile biomaterial. Fibrin forms branched networks built of laterally associated …

Integrin receptors are transmembrane proteins that bind to the extracellular matrix (ECM). In
most animal cell types integrins cluster together with adaptor proteins at focal adhesions that …

We fit turbidimetry data to obtain the number of protofibrils, Np, and the mass-length ratio, ν,
for each fibrin gel condition studied using a method previously proposed by Ferri et al [1]. For …