RAS and RHO proteins, which contribute to tumorigenesis and metastasis, undergo
posttranslational modification with an isoprenyl lipid by protein farnesyltransferase (FTase) or …

Protein geranylgeranyltransferase type I (GGTase-I) is responsible for the posttranslational
lipidation of CAAX proteins such as RHOA, RAC1, and cell division cycle 42 (CDC42). …

Hyperactive signaling through the RAS proteins is involved in the pathogenesis of many
forms of cancer. The RAS proteins and many other intracellular signaling proteins are either …

The RAS proteins undergo farnesylation of a carboxyl-terminal cysteine (the “C” of the
carboxyl-terminal CaaX motif). After farnesylation, the 3 amino acids downstream from the farnesyl …

Rheumatoid arthritis (RA) is an inflammatory joint disease with a neurological component
including depression, cognitive deficits, and pain, which substantially affect patients’ quality of …

Background Signalling through insulin-like growth factor 1 receptor (IGF-1R) is essential for
cell survival, but may turn pathogenic in uncontrolled tissue growth in tumours. In rheumatoid …

Proper physiological functioning of any cell type requires ordered chromatin organization. In
this context, cohesin complex performs important functions preventing premature separation …

Objectives Since low insulin-like growth factor (IGF) 1 is often linked to inflammation, we
analyze whether serum levels of IGF1 are associated with cardiovascular disease (CVD) in …

Follicular T helper (Tfh) cells are recognized by the expression of CXCR5 and the
transcriptional regulator Bcl-6. Tfh cells control B cell maturation and antibody production, and if …

Survivin is known as an inhibitor of apoptosis and a positive regulator of cell division. We
have recently identified survivin as a predictor of joint destruction in patients with rheumatoid …