Hyperuricemia induces endothelial dysfunction. Background Hyperuricemia has been linked
to cardiovascular and renal diseases, possibly through the generation of reactive oxygen …

Elevated levels of serum uric acid (UA) are commonly associated with primary pulmonary
hypertension but have generally not been thought to have any causal role. Recent …

Activated arginase has been implicated in many diseases including cancer, immune cell
dysfunction, infections, and vascular disease. Enhanced arginase activity has been reported in …

There are a number of respiratory diseases characterized by the presence of excess
neutrophil elastase (NE) activity in tissues, including cystic fibrosis and chronic obstructive …

We previously described therapeutic opportunities provided by capsid- and expression
cassette-optimized adeno-associated virus serotype 6 (AAV6) vectors to suppress tumor growth …

Recently, we showed that administration of the angiotensin-converting enzyme inhibitor
enalapril to aged rats attenuated muscle strength decline and mitigated apoptosis in the …

An orally active vaccine capable of boosting SARS-CoV-2 immune responses in previously
infected or vaccinated individuals would help efforts to achieve and sustain herd immunity. …

Alpha‐1‐antitrypsin deficiency (AATD) is an inherited disease characterized by emphysema
and liver disease. AATD is most often caused by a single amino acid substitution at amino …

We examined which isoforms of protein kinase C (PKC) may be involved in the regulation of
cationic amino acid transporter-1 (CAT-1) transport activity in cultured pulmonary artery …

We have previously shown that an AAV6-based vaccine generates high levels of antigen-specific
CD8 + T cells. Further modifications described here led to significantly increased …