Following activation, macrophages undergo extensive metabolic rewiring 1 , 2 . Production
of itaconate through the inducible enzyme IRG1 is a key hallmark of this process 3 . Itaconate …

Polyketides, the ubiquitous products of secondary metabolism in microorganisms, are made
by a process resembling fatty acid biosynthesis that allows the suppression of reduction or …

Mechanochemistry enables enzymatic cleavage of cellulose into glucose without bulk
solvents, acids, other aggressive reagents, or substrate pre‐treatment. This clean …

The fungal metabolite lovastatin (1) 1 and its derivatives are cholesterol-lowering drugs that
act as potent inhibitors of (3S)-hydroxy-3-methylglutaryl-coenzyme A reductase. 2 Although …

Metabolic regulation has been recognized as a powerful principle guiding immune
responses. Inflammatory macrophages undergo extensive metabolic rewiring 1 marked by the …

The Ginkgo biloba extract EGb761 was tested for its ability to inhibit the major human cytochrome
P450 enzymes (CYPs). The full extract was found to strongly inhibit CYP2C9 (K i =14±…

Ulcerative colitis is a dynamic, chronic inflammatory condition of the colon associated with an
increased colon cancer risk. Ginkgo biloba is a putative antioxidant and has been used for …

Enantioselective hydroxylation of one specific methylene in the presence of many similar
groups is debatably the most challenging chemical transformation. Although chemists have …

Norcarane (1) and spiro[2.5]octane (2) yield different product distributions depending on
whether they are oxidized via concerted, radical, or cationic mechanisms. For this reason, these …

Lovastatin biosynthesis in Aspergillus terreus involves two unusual type I multifunctional
polyketide syntheses (PKSs). Lovastatin nonaketide synthase (LNKS), the product of the lovB …