The last decade has seen a sharp increase in the number of scientific publications describing
physiological and pathological functions of extracellular vesicles (EVs), a collective term …

Some pathogens (eg, Mycobacterium tuberculosis, Toxoplasma gondii, Leishmania spp)
have been shown to persist in their host after clinical cure, establishing the risk of disease …

To dissect the controversial roles of type 1 and type 2 cytokines to the pathogenesis of
schistosomiasis, we generated IL-10/IL-4-and IL-10/IL-12-deficient mice that develop highly …

Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma
mansoni. With the World Health Organization's goal to eliminate schistosomiasis as a global …

Resistance to many intestinal nematodes is dependent on the induction of polarized type 2
cytokine responses, whereas type 1 responses can exacerbate these infections. The …

Background Penetration of skin, migration through tissues and establishment of long-lived
intravascular partners require Schistosoma parasites to successfully manipulate definitive …

Padraic Fallon recently presented an excellent summary of cytokine responses and
immunopathology in infected mice and humans1. We wish to take issue with several points, …

Background Novel methods to identify anthelmintic drug and vaccine targets are urgently
needed, especially for those parasite species currently being controlled by singular, often …

Background The Sperm-coating protein/Tpx-1/Ag5/PR-1/Sc7 (SCP/TAPS) domain is found
across phyla and is a major structural feature of insect allergens, mammalian sperm proteins …

Similar to other metazoan pathogens, Schistosoma mansoni undergoes transcriptional and
developmental regulation during its complex lifecycle and host interactions. DNA methylation …