We detected clonal mosaicism for large chromosomal anomalies (duplications, deletions
and uniparental disomy) using SNP microarray data from over 50,000 subjects recruited for …

Thrombotic thrombocytopenic purpura (TTP) is a life-threatening illness caused by deficiency
of the vWF-cleaving protease ADAMTS13. Here we show that ADAMTS13-deficient mice …

People with kidney disease are disproportionately affected by atherosclerosis for unclear
reasons. Soluble urokinase plasminogen activator receptor (suPAR) is an immune-derived …

Background: Factor VIII (FVIII) and its carrier protein von Willebrand factor (VWF) are associated
with risk of arterial and venous thrombosis and with hemorrhagic disorders. We aimed to …

The plasma glycoprotein von Willebrand factor (VWF) exhibits fivefold antigen level variation
across the normal human population determined by both genetic and environmental factors…

Deep vein thrombosis and pulmonary embolism, collectively defined as venous
thromboembolism (VTE), are the third leading cause of cardiovascular death in the United States. …

Genome-wide association studies (GWASs) have identified loci for erythrocyte traits in primarily
European ancestry populations. We conducted GWAS meta-analyses of six erythrocyte …

Erythropoietin (EPO) stimulates erythroid differentiation and maturation. Though the
transcriptional regulation of EPO has been well studied, the molecular determinants of EPO …

Thrombotic microangiopathy is characterized by microvascular thrombosis coupled with
thrombocytopenia, hemolytic anemia, and red blood cell fragmentation. Familiar to …

Background Thrombolytic recombinant tissue plasminogen activator (r-tPA) treatment is the
only pharmacologic intervention available in the ischemic stroke acute phase. This treatment …