User profiles for Karl Kumbier

Karl Kumbier

University of California San Francisco
Verified email at berkeley.edu
Cited by 2494

Definitions, methods, and applications in interpretable machine learning

WJ Murdoch, C Singh, K Kumbier… - Proceedings of the …, 2019 - National Acad Sciences
Machine-learning models have demonstrated great success in learning complex patterns
that enable them to make predictions about unobserved data. In addition to using models for …

Interpretable machine learning: definitions, methods, and applications

WJ Murdoch, C Singh, K Kumbier, R Abbasi-Asl… - arXiv preprint arXiv …, 2019 - arxiv.org
Machine-learning models have demonstrated great success in learning complex patterns
that enable them to make predictions about unobserved data. In addition to using models for …

Iterative random forests to discover predictive and stable high-order interactions

S Basu, K Kumbier, JB Brown… - Proceedings of the …, 2018 - National Acad Sciences
Genomics has revolutionized biology, enabling the interrogation of whole transcriptomes,
genome-wide binding sites for proteins, and many other molecular processes. However, …

[PDF][PDF] Curating a COVID-19 data repository and forecasting county-level death counts in the United States

N Altieri, RL Barter, J Duncan, R Dwivedi, K Kumbier… - 2021 - assets.pubpub.org
As the COVID-19 outbreak evolves, accurate forecasting continues to play an extremely
important role in informing policy decisions. In this article, we present our continuous curation of …

A debiased MDI feature importance measure for random forests

X Li, Y Wang, S Basu, K Kumbier… - Advances in Neural …, 2019 - proceedings.neurips.cc
Tree ensembles such as Random Forests have achieved impressive empirical success across
a wide variety of applications. To understand how these models make predictions, people …

Artificial intelligence and statistics

B Yu, K Kumbier - Frontiers of Information Technology & Electronic …, 2018 - Springer
Artificial intelligence (AI) is intrinsically data-driven. It calls for the application of statistical
concepts through human-machine collaboration during the generation of data, the …

[HTML][HTML] A novel random forest approach to revealing interactions and controls on chlorophyll concentration and bacterial communities during coastal phytoplankton …

Y Cheng, VN Bhoot, K Kumbier, MP Sison-Mangus… - Scientific Reports, 2021 - nature.com
Increasing occurrence of harmful algal blooms across the land–water interface poses significant
risks to coastal ecosystem structure and human health. Defining significant drivers and …

Selection of optimal cell lines for high-content phenotypic screening

L Heinrich, K Kumbier, L Li, SJ Altschuler… - ACS chemical …, 2023 - ACS Publications
High-content microscopy offers a scalable approach to screen against multiple targets in a
single pass. Prior work has focused on methods to select “optimal” cellular readouts in …

A scalable screening platform for phenotypic subtyping of ALS patient-derived fibroblasts

K Kumbier, M Roth, Z Li, J Lazzari-Dean, C Waters… - bioRxiv, 2022 - biorxiv.org
A major challenge for understanding and treating Amyotrophic Lateral Sclerosis (ALS) is that
most patients have no known genetic cause. Even within defined genetic subtypes, patients …

Refining interaction search through signed iterative random forests

K Kumbier, S Basu, JB Brown, S Celniker, B Yu - bioRxiv, 2018 - biorxiv.org
Advances in supervised learning have enabled accurate prediction in biological systems
governed by complex interactions among biomolecules. However, state-of-the-art predictive …