During rest, brain activity is synchronized between different regions widely distributed throughout
the brain, forming functional networks. However, the molecular mechanisms supporting …

Major depression is conditionally linked to a polymorphism of the human serotonin transporter
gene (SLC6A4). During the presentation of aversive, but not pleasant, pictures, healthy …

OBJECTIVE: Alcohol and other drugs of abuse stimulate dopamine release in the ventral
striatum, which includes the nucleus accumbens, a core region of the brain reward system, and …

Rationale Animal experiments have provided evidence that the striatum and medial
prefrontal cortex play a predominant role in the acquisition and maintenance of drug-seeking …

Background The effectiveness acamprosate (calcium bisacetylhomotaurinate) as a treatment
to maintain abstinence in alcohol-dependent patients was assessed for 1 year. Methods: …

ContextHypothetically, topiramate can improve drinking outcomes among alcohol-dependent
individuals by reducing alcohol's reinforcing effects through facilitation of γ-aminobutyric …

Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic
architecture or its genetic relationship with other disorders. To discover loci associated …

Catechol-O-methyltransferase (COMT) degrades the catecholamine neurotransmitters
dopamine, epinephrine, and norepinephrine. A functional polymorphism in the COMT gene (val …

Background Gambling and gaming disorders have been included as “disorders due to
addictive behaviors” in the International Classification of Diseases (ICD-11). Other problematic …

Background: A number of clinical trials have been undertaken to determine the efficacy of
acamprosate in the maintenance of abstinence in alcohol‐dependent individuals. However, …