The majority of epilepsies are focal in origin, with seizures emanating from one brain region.
Although focal epilepsies often arise from structural brain lesions, many affected individuals …

Background Surgery is a widely accepted treatment option for drug-resistant focal epilepsy.
A detailed analysis of longitudinal postoperative seizure outcomes and use of antiepileptic …

We report detailed functional analyses and genotype-phenotype correlations in 392 individuals
carrying disease-causing variants in SCN8A, encoding the voltage-gated Na + channel …

Introduction: Therapy with current antiepileptic drugs aims at reducing the likelihood of
seizure occurrence rather than influencing the underlying disease process. Therefore, …

Emerging evidence indicates that epileptic encephalopathies are genetically highly
heterogeneous, underscoring the need for large cohorts of well-characterized individuals to further …

Objective: SCN8A encodes the sodium channel voltage-gated α8-subunit (Na v 1.6). SCN8A
mutations have recently been associated with epilepsy and neurodevelopmental disorders. …

Sequencing-based studies have identified novel risk genes associated with severe epilepsies
and revealed an excess of rare deleterious variation in less-severe forms of epilepsy. To …

Familial Adult Myoclonic Epilepsy (FAME) is a genetically heterogeneous disorder characterized
by cortical tremor and seizures. Intronic TTTTA/TTTCA repeat expansions in SAMD12 (…

Familial Adult Myoclonic Epilepsy (FAME) is characterised by cortical myoclonic tremor usually
from the second decade of life and overt myoclonic or generalised tonic-clonic seizures. …

Objective To evaluate factors predicting efficacy, retention, and tolerability of add‐on brivaracetam
( BRV ) in clinical practice. Methods A multicenter, retrospective cohort study recruiting …