Background Obesity is associated with vitamin D deficiency, and both are areas of active
public health concern. We explored the causality and direction of the relationship between …

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic
outcomes, independent of overall adiposity. To increase our understanding of the genetic …

The pandemic increase in obesity is inversely associated with vitamin D levels. While a
higher BMI was causally related to lower 25-hydroxyvitamin D (25(OH)D), no evidence was …

Peptides have long been recognized as a promising group of therapeutic substances to treat
various diseases. Delivery systems for peptides have been under development since the …

Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic
consequences independent of overall adiposity. WHR is heritable, but few genetic variants …

Background Low plasma 25-hydroxyvitamin D (25[OH]D) concentration is associated with
high arterial blood pressure and hypertension risk, but whether this association is causal is …

To dissect the genetic architecture of blood pressure and assess effects on target organ
damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 …

Key points • Contradictory findings have been reported concerning the function of irisin and
its precursor gene, skeletal muscle FNDC5, in energy homeostasis and metabolic health, …

In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood
pressure to identify genes, tissues, phenomes and medication contexts of blood pressure …

High blood pressure is a major risk factor for cardiovascular disease and premature death.
However, there is limited knowledge on specific causal genes and pathways. To better …