Background Macrophages are one of the most important players in the tumor microenvironment.
The polarization status of tumor associated macrophages into a pro-inflammatory type …

Aptamers have in recent years emerged as a viable alternative to antibodies. High-throughput
sequencing (HTS) has revolutionized aptamer research by increasing the number of …

In vivo phage display is widely used for identification of organ- or disease-specific homing
peptides. However, the current in vivo phage biopanning approaches fail to assess …

Nanotechnology-based drug design offers new possibilities for the use of nanoparticles in
imaging and targeted therapy of tumours. Due to their tumour-homing ability, nano-…

We created a 3D cell co-culture model by combining nanoengineered mesenchymal stem
cells (MSCs) with the metastatic breast cancer cell line MDA-MD-231 and primary breast …

Targeted therapies have increased the treatment options for triple-negative breast cancer
patients. However, the paucity of targetable biomarkers and tumor heterogeneity have limited …

In vivo peptide-phage display is an unbiased technique for mapping of the vascular diversity
and identification of homing peptides. This chapter is intended to serve as a structured …

Purine auxotrophy is an abundant trait among eukaryotic parasites and a typical marker for
many budding yeast strains. Supplementation with an additional purine source (such as …

Genome-scale metabolic modeling is widely used to study the impact of metabolism on the
phenotype of different organisms. While substrate modeling reflects the potential distribution …

Targeted therapies have increased the treatment options for triple-negative breast cancer
patients. However, the paucity of targetable biomarkers and tumour heterogeneity have limited …