Cancer immunotherapy via dendritic cells
K Palucka, J Banchereau - Nature Reviews Cancer, 2012 - nature.com
Cancer immunotherapy attempts to harness the power and specificity of the immune system
to treat tumours. The molecular identification of human cancer-specific antigens has allowed …
to treat tumours. The molecular identification of human cancer-specific antigens has allowed …
Immunobiology of dendritic cells
…, YJ Liu, B Pulendran, K Palucka - Annual review of …, 2000 - annualreviews.org
Dendritic cells (DCs) are antigen-presenting cells with a unique ability to induce primary
immune responses. DCs capture and transfer information from the outside world to the cells of …
immune responses. DCs capture and transfer information from the outside world to the cells of …
IL-6 switches the differentiation of monocytes from dendritic cells to macrophages
…, J Banchereau, J Davoust, A Karolina Palucka - Nature …, 2000 - nature.com
Monocytes can give rise to either antigen presenting dendritic cells (DCs) or scavenging
macrophages. This differentiation is initiated when monocytes cross the endothelium. But the …
macrophages. This differentiation is initiated when monocytes cross the endothelium. But the …
[PDF][PDF] Dendritic-cell-based therapeutic cancer vaccines
K Palucka, J Banchereau - Immunity, 2013 - cell.com
The past decade has seen tremendous developments in novel cancer therapies through the
targeting of tumor-cell-intrinsic pathways whose activity is linked to genetic alterations and …
targeting of tumor-cell-intrinsic pathways whose activity is linked to genetic alterations and …
In breast carcinoma tissue, immature dendritic cells reside within the tumor, whereas mature dendritic cells are located in peritumoral areas
…, J Valladeau, J Davoust, KA Palucka… - The Journal of …, 1999 - rupress.org
We have analyzed the presence of immature and mature dendritic cells (DCs) within
adenocarcinoma of the breast using immunohistochemistry. Immature DCs were defined by …
adenocarcinoma of the breast using immunohistochemistry. Immature DCs were defined by …
Sensing pathogens and tuning immune responses
B Pulendran, K Palucka, J Banchereau - Science, 2001 - science.org
The immune system is capable of making qualitatively distinct responses against different
microbial infections, and recent advances are starting to reveal how it manages this complex …
microbial infections, and recent advances are starting to reveal how it manages this complex …
[PDF][PDF] Glioma progression is shaped by genetic evolution and microenvironment interactions
The factors driving therapy resistance in diffuse glioma remain poorly understood. To
identify treatment-associated cellular and genetic changes, we analyzed RNA and/or DNA …
identify treatment-associated cellular and genetic changes, we analyzed RNA and/or DNA …
Flt3-ligand and granulocyte colony-stimulating factor mobilize distinct human dendritic cell subsets in vivo
…, J Davoust, J Fay, K Palucka - The Journal of …, 2000 - journals.aai.org
Dendritic cells (DCs) have a unique ability to stimulate naive T cells. Recent evidence suggests
that distinct DC subsets direct different classes of immune responses in vitro and in vivo. …
that distinct DC subsets direct different classes of immune responses in vitro and in vivo. …
Dendritic cells as the terminal stage of monocyte differentiation
KA Palucka, N Taquet, F Sanchez-Chapuis… - The Journal of …, 1998 - journals.aai.org
Monocytes (MO) cultured for≥ 5 days with either macrophage-CSF (M-CSF) or granulocyte
macrophage (GM)-CSF and IL-4 differentiated without concomitant proliferation into CD14+ …
macrophage (GM)-CSF and IL-4 differentiated without concomitant proliferation into CD14+ …
[PDF][PDF] Global analyses of human immune variation reveal baseline predictors of postvaccination responses
…, F Cheung, G Obermoser, D Chaussabel, K Palucka… - Cell, 2014 - cell.com
A major goal of systems biology is the development of models that accurately predict
responses to perturbation. Constructing such models requires the collection of dense …
responses to perturbation. Constructing such models requires the collection of dense …