The conduction of electrical signals through cardiac tissue is essential for maintaining the
function of the heart, and conduction abnormalities are known to potentially lead to life-…

Computational modeling has contributed significantly to present understanding of cardiac
electrophysiology including cardiac conduction, excitation-contraction coupling, and the …

Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) hold great
potential for drug screening applications. However, their usefulness is limited by the relative …

While cardiomyocytes differentiated from human induced pluripotent stems cells (hiPSCs)
hold great promise for drug screening, the electrophysiological properties of these cells can …

Mathematical models based on homogenized representation of cardiac tissue have greatly
improved our understanding of cardiac electrophysiology. However, these models are too …

Cell-based models of excitable tissues offer the advantage of cell-level precision, which
cannot be achieved using traditional homogenized electrophysiological models. However, this …

The EMI model represents excitable cells in a more accurate manner than traditional homogenized
models at the price of increased computational complexity. The increased complexity …

The bidomain model is considered to be the gold standard for numerical simulation of the
electrophysiology of cardiac tissue. The model provides important insights into the conduction …

Excitable cells are of vital importance in biology, and mathematical models have contributed
significantly to understand their basic mechanisms. However, classical models of excitable …

In the heart, electrophysiological dysregulation arises from defects at many biological levels
(from point mutations in ion channel proteins to gross structural abnormalities). These …