Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic
complications. Through trans-ancestry meta-analysis of genome-wide association studies of …

Elevated serum urate levels cause gout and correlate with cardiometabolic diseases via poorly
understood mechanisms. We performed a trans-ancestry genome-wide association study …

There are 10× more bacterial cells in our bodies from the microbiome than human cells. Viral
DNA is known to integrate in the human genome, but the integration of bacterial DNA has …

Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher
risk of kidney disease progression and cardiovascular events, but underlying mechanisms …

Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated
with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the …

Lateral gene transfer (LGT) is an all-encompassing term for the movement of DNA between
diverse organisms. LGT is synonymous with horizontal gene transfer, and the terms are used …

Estimated glomerular filtration rate (eGFR) reflects kidney function. Progressive eGFR-decline
can lead to kidney failure, necessitating dialysis or transplantation. Hundreds of loci from …

Lateral gene transfer (LGT) from bacteria to animals occurs more frequently than was
appreciated prior to the advent of genome sequencing. In 2007, LGT from bacterial Wolbachia …

Background Linking genetic risk loci identified by genome-wide association studies (GWAS)
to their causal genes remains a major challenge. Disease-associated genetic variants are …

Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include
genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted …