Breast cancers are either primarily resistant to chemotherapy (intrinsic resistance), or
respond to chemotherapy but later recur with a multidrug-resistant phenotype because of …

Regulated mRNA turnover is a highly important process, but its mechanism is poorly
understood. Using interleukin-2 (IL-2) mRNA as a model, we described a role for the JNK-signaling …

Expression of the Y-box protein YB-1 is increased in proliferating normal and cancer cells,
but its role in cell proliferation and cell cycle progression is unclear. We have identified a cell …

Intrinsic or acquired resistance to chemotherapy is responsible for failure of current treatment
regimens in breast cancer patients. The Y‐box protein YB‐1 regulates expression of the P‐…

Genotoxic stress leads to nuclear translocation of the Y-box transcription factor YB-1 and
enhanced expression of the multidrug resistance gene MDR1. Because hyperthermia is used …

The multifunctional DNA- and RNA-associated Y-box protein 1 (YB-1) specifically binds to
splicing recognition motifs and regulates alternative splice site selection. Here, we identify the …

Circadian clocks govern a wide range of cellular and physiological functions in various
organisms. Recent evidence suggests distinct functions of local clocks in peripheral mammalian …

YB-1 protein levels are elevated in most human breast cancers, and high YB-1 levels have
been correlated with drug resistance and poor clinical outcome. YB-1 is a stress-responsive, …

The adenovirus early proteins E1A and E1B-55kDa are key regulators of viral DNA replication,
and it was thought that targeting of p53 by E1B-55kDa is essential for this process. Here …

Immunological competence declines progressively with age, resulting in increased susceptibility
of the elderly to infection and impaired responses to vaccines. Underlying mechanisms …