A new model for electron flow during anaerobic digestion: direct interspecies electron transfer to Methanosaeta for the reduction of carbon dioxide to methane

…, D Shrestha, M Embree, K Zengler… - Energy & …, 2014 - pubs.rsc.org
Anaerobic conversion of organic wastes and biomass to methane is an important bioenergy
strategy, which depends on poorly understood mechanisms of interspecies electron transfer …

Cultivating the uncultured

K Zengler, G Toledo, M Rappé… - Proceedings of the …, 2002 - National Acad Sciences
The recent application of molecular phylogeny to environmental samples has resulted in the
discovery of an abundance of unique and previously unrecognized microorganisms. The …

Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis

…, PC Dorrestein, A Grier, SR Gill, K Zengler… - Science translational …, 2017 - science.org
The microbiome can promote or disrupt human health by influencing both adaptive and
innate immune functions. We tested whether bacteria that normally reside on human skin …

Methane formation from long-chain alkanes by anaerobic microorganisms

K Zengler, HH Richnow, R Rosselló-Mora, W Michaelis… - Nature, 1999 - nature.com
Biological formation of methane is the terminal process of biomass degradation in aquatic
habitats where oxygen, nitrate, ferric iron and sulphate have been depleted as electron …

GABA-modulating bacteria of the human gut microbiota

…, C Liston, EJ Stewart, MJ Dubin, K Zengler… - Nature …, 2019 - nature.com
The gut microbiota affects many important host functions, including the immune response
and the nervous system 1 . However, while substantial progress has been made in growing …

[HTML][HTML] Establishing microbial composition measurement standards with reference frames

…, J Silverman, LS Zaramela, A Edlund, K Zengler… - Nature …, 2019 - nature.com
Differential abundance analysis is controversial throughout microbiome research. Gold
standard approaches require laborious measurements of total microbial load, or absolute …

[HTML][HTML] The microbiome extends to subepidermal compartments of normal skin

…, HI Chiang, SB Jiang, H Nagarajan, K Zengler… - Nature …, 2013 - nature.com
Commensal microbes on the skin surface influence the behaviour of cells below the epidermis.
We hypothesized that bacteria or their products exist below the surface epithelium and …

Tapping into microbial diversity

M Keller, K Zengler - Nature Reviews Microbiology, 2004 - nature.com
Even though significant advances have been made in understanding microbial diversity,
most microorganisms are still only characterized by 'molecular fingerprints' and have resisted …

[HTML][HTML] In silico method for modelling metabolism and gene product expression at genome scale

…, RD Smith, JN Adkins, K Zengler… - Nature …, 2012 - nature.com
Transcription and translation use raw materials and energy generated metabolically to create
the macromolecular machinery responsible for all cellular functions, including metabolism. …

Adaptive laboratory evolution—harnessing the power of biology for metabolic engineering

VA Portnoy, D Bezdan, K Zengler - Current opinion in biotechnology, 2011 - Elsevier
Adaptive laboratory evolution (ALE) strategies allow for the metabolic engineering of
microorganisms by combining genetic variation with the selection of beneficial mutations in an …