Small-molecule protein kinase inhibitors are widely used to elucidate cellular signaling
pathways and are promising therapeutic agents. Owing to evolutionary conservation of the ATP-…

DNA methylation is a major epigenetic mechanism for gene silencing. Whereas
methyltransferases mediate cytosine methylation, it is less clear how unmethylated regions in …

In the last decade, advances in high-throughput technologies such as DNA microarrays have
made it possible to simultaneously measure the expression levels of tens of thousands of …

Background Free fibula osteocutaneous flaps are the primary option for reconstruction after
segmental mandibulectomies. This study evaluates the impact of CT‐guided preoperative …

Malignant mesothelioma has been linked to asbestos exposure and generally has a poor
prognosis because it is often diagnosed in advanced stages and is refractory to conventional …

Intrinsic and acquired cellular resistance factors limit the efficacy of most targeted cancer
therapeutics. Synthetic lethal screens in lower eukaryotes suggest that networks of genes …

Background The tumor immune microenvironment has become the focus of research in
clear cell renal cell carcinoma (ccRCC) due to its important role in immune surveillance post …

The p21-activated kinases (Paks) serve as effectors of the Rho family GTPases Rac and
Cdc42. The six human Paks are divided into two groups based on sequence similarity. Group I …

A common polymorphism at codon 72 in the p53 tumor suppressor gene encodes either
proline (P72) or arginine (R72). Several groups have reported that in cultured cells, this …

This study demonstrates the feasibility of targeting a fibroblastic protein, NetG1, which can
limit PDAC tumorigenesis in vivo by reverting the protumorigenic properties of CAFs. Moreover…