Immune checkpoint antibodies that augment the programmed cell death protein 1 (PD-1)/PD-L1
pathway have demonstrated antitumor activity across multiple malignancies, and gained …

Epilepsy has been historically seen as a functional brain disorder associated with excessive
synchronization of large neuronal populations leading to a hypersynchronous state. Recent …

To derive tests for randomness, nonlinear-independence, and stationarity, we combine
surrogates with a nonlinear prediction error, a nonlinear interdependence measure, and linear …

Epileptic seizures are commonly characterized as ‘hypersynchronous states’. This habit is
doubly misleading, because seizures are not necessarily synchronous and are not …

Electroecenphalography (EEG) is an integral part of the diagnostic process in patients with
Creutzfeldt–Jakob disease (CJD). The EEG has therefore been included in the World Health …

We assess electrical brain dynamics before, during, and after 100 human epileptic seizures
with different anatomical onset locations by statistical and spectral properties of functionally …

OBJECTIVE: To test whether increasing synchronization of neuronal activity might be causally
related to seizure termination. METHODS: Neuronal synchronization was assessed by the …

Importance In critically ill patients with altered consciousness, continuous electroencephalogram
(cEEG) improves seizure detection, but is resource-consuming compared with routine …

Surgery is a valuable option for pharmacologically intractable epilepsy. However, significant
post-operative improvements are not always attained. This is due in part to our incomplete …

Conceptually and structurally simple mathematical models of coupled oscillator networks
can show a rich variety of complex dynamics, providing fundamental insights into many real-…