In December 2019, the first cases of infection with a novel coronavirus, SARS-CoV-2, were
diagnosed. Currently, there is no effective antiviral treatment for COVID-19. To address this …

Inflammatory cell death, or pyroptosis, is triggered by pathogenic infections or events. It is
executed by caspase-1 (in the canonical pyroptosis pathway) or caspase-11 (noncanonical …

Cysteine cathepsins normally function in the lysosomal degradation system where they are
critical for the maintenance of cellular homeostasis and the MHC II immune response, and …

Human cysteine cathepsins constitute an 11-membered family of proteases responsible for
degradation of proteins in cellular endosomal–lysosomal compartments as such, they play …

In December 2019, the first cases of a novel coronavirus infection were diagnosed in Wuhan,
China. Due to international travel and human-to-human transmission, the virus spread …

The subset of the proteome that contains enzymes in their catalytically active form can be
interrogated by using probes targeted toward individual specific enzymes. A subset of such …

Apical caspases initiate and effector caspases execute apoptosis. Reagents that can distinguish
between caspases, particularly apical caspases-8, 9, and 10 are scarce and generally …

Proteases are enzymes that hydrolyze the peptide bond of peptide substrates and proteins.
Despite significant progress in recent years, one of the greatest challenges in the design and …

The aim of the study was to compare the effect of the substituent and its position in the aromatic
ring on the antioxidant activity of hexanoic acid esters obtained in reactions catalyzed by …

In December 2019, the first cases of infection with a novel coronavirus, SARS-CoV-2, were
diagnosed in Wuhan, China. Due to international travel and human-to-human transmission, …