Genetic circuits and reaction cascades are of great importance for synthetic biology,
biochemistry and bioengineering. An open question is how to maximize the modularity of their …

The emergence of homeostatic mechanisms that enable maintenance of an intracellular
steady state during growth was critical to the advent of cellular life. Here, we show that …

Building a live cell from non‐living building blocks would be a fundamental breakthrough in
biological sciences, and it would enable engineering new lineages of life, not directly …

Synthetic cells are engineered vesicles that can mimic one or more salient features of life.
These features include directed localization, sense‐and‐respond behavior, gene expression, …

Employing concepts from physics, chemistry and bioengineering, 'learning-by-building'
approaches are becoming increasingly popular in the life sciences, especially with researchers …

One widely held model of early life suggests primitive cells consisted of simple RNA-based
catalysts within lipid compartments. One possible selective advantage conferred by an …

Engineering synthetic minimal cells provide a controllable chassis for studying the biochemical
principles of natural life, increasing our understanding of complex biological processes. …

The ability to monitor and perturb RNAs in living cells would benefit greatly from a modular
protein architecture that targets unmodified RNA sequences in a programmable way. We …

Synthetic cells can mimic the intricate complexities of live cells, while mitigating the level of
noise that is present natural systems; however, many crucial processes still need to be …

In order to analyze how a signal transduction network converts cellular inputs into cellular
outputs, ideally one would measure the dynamics of many signals within the network …