Reactive oxygen, nitrogen, and sulfur species, referred to as ROS, RNS, and RSS,
respectively, are produced during normal cell function and in response to various stimuli. An …

Hydrogen peroxide (H 2 O 2 ) acts as a second messenger that can mediate intracellular signal
transduction via chemoselective oxidation of cysteine residues in signaling proteins. This …

Protein sulfenylation is a post-translational modification of emerging importance in higher
eukaryotes. However, investigation of its diverse roles remains challenging, particularly within …

Oxidation of cysteine to sulfenic acid has emerged as a biologically relevant post-translational
modification with particular importance in redox-mediated signal transduction; however, …

The polarizable sulfur atom in cysteine is subject to numerous post-translational oxidative
modifications in the cellular milieu, which regulates a wide variety of biological phenomena …

Background Reactive oxygen species-mediated cysteine sulfenic acid modification has
emerged as an important regulatory mechanism in cell signaling. The stability of sulfenic acid in …

Controlled generation of reactive oxygen species orchestrates numerous physiological
signaling events (Finkel, T. (2011) Signal transduction by reactive oxygen species. J. Cell Biol. …

Mannose 6-phosphate receptors (MPRs) deliver lysosomal hydrolases from the Golgi to
endosomes and then return to the Golgi complex. TIP47 recognizes the cytoplasmic domains of …

▪ Abstract Since the discovery of enzymes as biological catalysts, study of their enormous
catalytic power and exquisite specificity has been central to biochemistry. Nevertheless, there …

Life on Earth emerged in a hydrogen sulfide (H 2 S)-rich environment eons ago and with it
protein persulfidation mediated by H 2 S evolved as a signaling mechanism. Protein …