Background SARS-CoV-2 is a recently emerged respiratory pathogen that has significantly
impacted global human health. We wanted to rapidly characterise the transcriptomic, …

The PDZ-domain-containing sorting nexin 27 (SNX27) promotes recycling of internalized
transmembrane proteins from endosomes to the plasma membrane by linking PDZ-dependent …

Protein kinase B (Akt) plays a central role in cellular regulation, although many of the
physiologically relevant substrates for the kinase remain to be identified. In this study, we have …

The increasing use of nanoparticles in medicine has raised concerns over their ability to gain
access to privileged sites in the body. Here, we show that cobalt–chromium nanoparticles (…

Following endocytosis into the endosomal network, integral membrane proteins undergo
sorting for lysosomal degradation or are retrieved and recycled back to the cell surface. Here …

Retromer is a protein assembly that plays a central role in orchestrating export of
transmembrane-spanning cargo proteins from endosomes into retrieval pathways destined for the …

The FERM-like domain–containing sorting nexins of the SNX17/SNX27/SNX31 family have
been proposed to mediate retrieval of transmembrane proteins from the lysosomal pathway. …

Identification of proteins by tandem mass spectrometry requires a reference protein database,
but these are only available for model species. Here we demonstrate that, for a non-model …

Endosomal recycling of transmembrane proteins requires sequence-dependent recognition
of motifs present within their intracellular cytosolic domains. In this study, we have …

Multiple coronaviruses have emerged independently in the past 20 years that cause lethal
human diseases. Although vaccine development targeting these viruses has been …