microRNAs (miRNAs) regulate expression by promoting degradation or repressing translation
of target transcripts. miRNA target sites have been catalogued in databases based on …

comb-p is a command-line tool and a python library that manipulates BED files of possibly
irregularly spaced P-values and (1) calculates auto-correlation, (2) combines adjacent P-…

Epigenetics refers to mitotically heritable changes to the DNA, which do not affect the DNA
sequence, but can influence its function. Currently, DNA methylation is the most studied …

Although most cases of chronic obstructive pulmonary disease (COPD) occur in smokers, only
a fraction of smokers develop the disease. We hypothesized distinct molecular signatures …

In vitiligo, the autoimmune destruction of epidermal melanocytes produces white spots that
can be repigmented by melanocyte precursors from the hair follicles, following stimulation …

Hypertensive disorders of pregnancy (HDP) are associated with low birth weight, shorter
gestational age, and increased risk of maternal and offspring cardiovascular diseases later in …

Human papillomavirus (HPV) infection distinctly alters methylation patterns in HPV-associated
cancer. We have recently reported that HPV E7-dependent promoter hypermethylation …

Background Prenatal alcohol exposure can result in fetal alcohol spectrum disorders ( FASD
). Not all women who consume alcohol during pregnancy have children with FASD and …

Chronic Obstructive Pulmonary Disease (COPD) is the third leading cause of mortality in the
United States; however, COPD has heterogeneous clinical phenotypes. This is the first …

Background: Small studies have recently suggested that there are specific plasma metabolic
signatures in chronic obstructive pulmonary disease (COPD), but there have been no large …