BACKGROUND The key to a more effective diagnosis, prognosis, and therapeutic management
of prostate cancer (PCa) could lie in the direct analysis of cancer tissue. In this study, by …

Objectives Physical inactivity and sedentary behaviour are associated with higher breast
cancer risk in observational studies, but ascribing causality is difficult. Mendelian randomisation …

PURPOSE A polygenic risk score (PRS) consisting of 313 common genetic variants (PRS313)
is associated with risk of breast cancer and contralateral breast cancer. This study aimed …

Understanding molecular mechanisms that underpin azoospermia and discovery of biomarkers
that could enable reliable, non-invasive diagnosis are highly needed. Using label-free …

Background Genome-wide association studies (GWAS) have identified multiple common
breast cancer susceptibility variants. Many of these variants have differential associations by …

Germline protein truncating variants (PTVs) in the FANCM gene have been associated with
a 2–4-fold increased breast cancer risk in case-control studies conducted in different …

Tumours presenting BRCAness profile behave more aggressively and are more invasive as
a consequence of their complex genetic and epigenetic alterations, caused by impaired …

Germline copy number variants (CNVs) are pervasive in the human genome but potential
disease associations with rare CNVs have not been comprehensively assessed in large …

Purpose We aimed to establish the spectrum of BRCA1/2 mutations among the breast
cancer (BC) patients from the Republic of Macedonia. Methods We used targeted next-generation …

Digynic triploidy was found in 15 cases, whereas diandric triploidy was found in nine of the
cases. The results showed that due to the histomorphological overlap between partial molar …