Tauopathies are a heterogeneous group of neurodegenerative dementias involving
perturbations in the levels, phosphorylation, or mutations of the microtubule-binding protein Tau. …

Purpose Amyloid fibrils are associated with a variety of human protein misfolding and protein
deposition diseases. Previous studies have shown that bovine crystallins form amyloid …

Amyloid fibrils are fibrous β-structures that derive from abnormal folding and assembly of
peptides and proteins. Despite a wealth of structural studies on amyloids, the nature of the …

The folding of β-structured, fibrous proteins is a largely unexplored area. A class of such
proteins is used by viruses as adhesins, and recent studies revealed novel β-structured motifs …

Although the involvement of pathological tau in neurodegenerative dementias is indisputable,
its physiological roles have remained elusive in part because its abrogation has been …

Tau accumulation is clearly linked to pathogenesis in Alzheimer’s disease and other
Tauopathies. However, processes leading to Tau fibrillization and reasons for its pathogenicity …

Although Tau accumulation is clearly linked to pathogenesis in Alzheimer's disease and other
Tauopathies, the mechanism that initiates the aggregation of this highly soluble protein in …

Abnormally phosphorylated Tau protein, the major component of neurofibrillary tangles, is
critical in the pathogenesis of Alzheimer's disease and related Tauopathies. We used …

Adenovirus fibres are trimeric proteins that consist of a globular C-terminal domain, a central
fibrous shaft and an N-terminal part that attaches to the viral capsid. In the presence of the …

Introduction: Drosophila melanogaster offers a powerful expedient and economical system
with facile genetics. Because of the high sequence and functional conservation with human …