Oxygen is one of the critically defining elements resulting in the existence of eukaryotic life
on this planet. The rise and fall of this element can be tracked through time and corresponds …

Angiogenesis is an essential neovascularisation process, which if recapitulated in 3D in vitro,
will provide better understanding of endothelial cell (EC) behaviour. Various cell types and …

Background Cancer-associated fibroblasts (CAFs) are highly differentiated and heterogeneous
cancer-stromal cells that promote tumour growth, angiogenesis and matrix remodelling. …

Aim: We hypothesized that delivery of mesenchymal stem cells (MSCs) in a biomimetic
collagen scaffold improves wound healing in a diabetic mouse model. Materials & methods: …

Highlights • There is increasing interest in the role of immune cells in cancer progression. •
Move from 2D in vitro research to 3D complex disease models. • 3D models are used to study …

Photochemical internalisation (PCI) is a means of achieving spatio-temporal control of cytosolic
drug delivery using sub-lethal photodynamic therapy (PDT), with a photosensitiser that …

Photochemical internalisation (PCI) is a method for enhancing delivery of drugs to their
intracellular target sites of action. In this study we investigated the efficacy of PCI using a …

Pancreatic cancer is a unique cancer in that up to 90% of its tumour mass is composed of a
hypovascular and fibrotic stroma. This makes it extremely difficult for chemotherapies to be …

Pazopanib is a tyrosine kinase inhibitor used to treat renal cell carcinoma. Few in vitro studies
investigate its effects towards cancer cells or endothelial cells in the presence of cancer. …

Recent advancements in 3D in vitro culture have allowed for the development of cancer tissue
models which accurately recapitulate the tumour microenvironment. Consequently, there …