Kleefstra syndrome (KS) is a neurodevelopmental disorder caused by mutations in the histone
methyltransferase EHMT1. To study the impact of decreased EHMT1 function in human …

Epilepsy, intellectual and cortical sensory deficits, and psychiatric manifestations are the most
frequent manifestations of mitochondrial diseases. How mitochondrial dysfunction affects …

Ion channels of the DEG/ENaC family share a similar structure but serve strikingly diverse
biological functions, such as Na + reabsorption, mechanosensing, proton-sensing, …

Epigenetic regulation of gene transcription plays a critical role in neural network development
and in the etiology of Intellectual Disability (ID) and Autism Spectrum Disorder (ASD). …

The degenerin/epithelial Na+ channel family (DEG/ENaC) is a superfamily comprised of
numerous ion channels with correspondingly diverse functions and expression patterns. It …

Neurodevelopmental Disorders (NDDs) have a severe impact on affected individuals. Social
and cognitive problems emerge, often accompanied by intellectual disability and/or autism …

Background Sponges (Porifera) are nerve- and muscleless metazoa, but display coordinated
motor reactions. Therefore, they represent a valuable phylum to investigate coordination …

Background Cnidocytes, the eponymous cell type of the Cnidaria, facilitate both sensory and
secretory functions and are among the most complex animal cell types known. In addition to …

Background Whole cell patch clamp recording and intracellular Ca 2+ imaging were carried
out on rat cultured dorsal root ganglion (DRG) neurones to characterize the actions of crude …

Background The trochozoan excitatory peptide (EP) and its ortholog, the arthropod CCHamide,
are neuropeptides that are only investigated in very few animal species. Previous studies …