Antibody fragments can recognize their cognate antigen with high affinity and can be produced
at high yields, but generally display rapid blood clearance profiles. For pharmaceutical …

DNA-encoded chemical libraries, ie, collections of compounds individually coupled to distinctive
DNA fragments serving as amplifiable identification barcodes, represent a new tool for …

Acute myeloid leukemia (AML) is a rapidly progressing disease that is accompanied by a
strong increase in microvessel density in the bone marrow. This observation prompted us to …

Background Brain metastases (BM) are a frequent complication of malignant melanoma (MM),
with limited treatment options and poor survival. Prevention of BM could be more effective …

The antibody-mediated targeted delivery of cytokines, growth factors and immunomodulators
offers great potential for the therapy of cancer and other serious conditions. Interferon-…

Initiation of a tumor-directed immune response and appropriate modulation of its progress
are key issues in cancer immunotherapy. Combinatorial strategies addressing both aspects …

Purpose : We investigated the therapeutic action of F8-IL2, a fusion protein consisting of the
F8 antibody specific to the alternatively spliced extradomain-A of fibronectin, in diabody …

Tracking single extravasating cancer cells using multimodal correlative microscopy
uncovers a brain seeding mechanism involving endothelial remodeling driven by cancer cell–…

Objective This study was undertaken to quantify epilepsy‐related costs of illness (COI) in
Germany and identify cost‐driving factors. Methods COI were calculated among adults with …

Costimulation is an essential step in T-cell activation and hence, represents an important
aspect in cancer immunotherapy. 4-1BB, a member of the tumor necrosis factor receptor family, …