Healthy aging depends on removal of damaged cellular material that is in part mediated by
autophagy. The nutritional status of cells affects both aging and autophagy through as-yet-…

Myocardial fibrosis is a remodeling process of the extracellular matrix (ECM) following cardiac
stress. “Replacement fibrosis” describes the wound healing aspect in the acute phase of …

Long non-coding RNAs (lncRNAs) have potential as novel therapeutic targets in cardiovascular
diseases, but detailed information about the intercellular lncRNA shuttling mechanisms …

Arteriovenous malformations are a vascular anomaly typically present at birth, characterized
by an abnormal connection between an artery and a vein (bypassing the capillaries). These …

Background: Myocardial fibrosis is a hallmark of cardiac remodeling and functionally
involved in heart failure development, a leading cause of deaths worldwide. Clinically, no …

Circular RNAs (circRNAs) are endogenous, covalently circularised, non-protein-coding
RNAs generated from back-splicing. Most circRNAs are very stable, highly conserved, and …

Background: The transcription factor GATA2 orchestrates the expression of many endothelial-specific
genes, illustrating its crucial importance for endothelial cell function. The capacity …

Heart failure is a major contributor to the healthcare burden and mortality worldwide. Current
treatment strategies are able to slow down the transition of healthy heart into the failing one; …

Introduction Amyloidosis is caused by dysregulation of protein folding resulting in systemic
or organ specific amyloid aggregation. When affecting the heart, amyloidosis can cause …

Background Myocardial fibrosis is a hallmark of the failing heart, contributing to the most
common causes of deaths worldwide. Several microRNAs (miRNAs, miRs) controlling cardiac …