Signalling by members of the Hedgehog family of secreted proteins plays a central role in
the development of vertebrate and invertebrate embryos. In Drosophila, transduction of the …

Sonic hedgehog (Shh) signaling patterns many vertebrate tissues. shh mutations dramatically
affect mouse ventral forebrain and floor plate but produce minor defects in zebrafish. …

The ability of an animal to carry out its normal behavioral repertoire requires generation of an
enormous diversity of neurons and glia. The relative simplicity of the spinal cord makes this …

Dorsoventral patterning of the neural tube has a crucial role in shaping the functional
organization of the CNS. It is well established that hedgehog signalling plays a key role in …

The vertebrate spinal cord contains distinct classes of cells that form at precise dorsal–ventral
locations and express specific combinations of transcription factors. In amniotes, V2 cells …

Sonic hedgehog (Shh) is crucial for motoneuron development in chick and mouse. However,
zebrafish embryos homozygous for a deletion of the shh locus have normal numbers of …

Signaling by lipid-modified secreted glycoproteins of the Hedgehog family play fundamental
roles during pattern formation in animal development and in humans; dysfunction of …

Understanding how the vertebrate central nervous system develops and functions is a
major goal of a large body of biological research. This research is driven both by intellectual …

Vertebrate locomotor circuitry contains distinct classes of ventral spinal cord neurons which
each have particular functional properties. While we know some of the genes expressed by …

The spinal cord contains several distinct classes of neurons but it is still unclear how many of
the functional characteristics of these cells are specified. One of the most crucial functional …