The human intestine, colonized by a dense community of resident microbes, is a frequent
target of bacterial pathogens. Undisturbed, this intestinal microbiota provides protection from …

We have created a compendium of single cell transcriptomic data from the model organism
Mus musculus comprising more than 100,000 cells from 20 organs and tissues. These data …

The gut microbiota is a dense and diverse microbial community governed by dynamic
microbe–microbe and microbe–host interactions, the status of which influences whether enteric …

The composition of the gut microbiome in industrialized populations differs from those living
traditional lifestyles. However, it has been difficult to separate the contributions of human …

Improved understanding of the interplay between host and microbes stands to illuminate
new avenues for disease diagnosis, treatment, and prevention. Here, we provide a high-…

Intestinal microbiotas contain beneficial microorganisms that protect against pathogen
colonization; treatment with antibiotics disrupts the microbiota and compromises colonization …

Due to limitations on high-resolution strain tracking, selection dynamics during gut
microbiota colonization and transmission between hosts remain mostly mysterious. Here, we …

Imaging dense and diverse microbial communities has broad applications in basic microbiology
and medicine, but remains a grand challenge due to the fact that many species adopt …

ABSTRACT Changes to gut environmental factors such as pH and osmolality due to disease
or drugs correlate with major shifts in microbiome composition; however, we currently …

In Gram-positive bacteria, a thick cross-linked cell wall separates the membrane from the
extracellular space. Some surface-exposed proteins, such as the Listeria monocytogenes actin …