We performed RNA-seq and high-resolution mass spectrometry on 128 blood samples from
COVID-19-positive and COVID-19-negative patients with diverse disease severities and …

Maximal exercise-associated oxidative capacity is strongly correlated with health and
longevity in humans. Rats selectively bred for high running capacity (HCR) have improved …

Fibrin is essential for hemostasis; however, abnormal fibrin formation is hypothesized to
increase thrombotic risk. We previously showed that in situ thrombin generation on a cell's …

A critical application of metabolomics is the evaluation of tissues, which are often the primary
sites of metabolic dysregulation in disease. Laboratory rodents have been widely used for …

Gut microbial diurnal oscillations are important diet-dependent drivers of host circadian rhythms
and metabolism ensuring optimal energy balance. However, the interplay between diet, …

The molecular bases of how host genetic variation impacts the gut microbiome remain
largely unknown. Here we used a genetically diverse mouse population and applied systems …

Multi-omics analysis is a powerful and increasingly utilized approach to gain insight into
complex biological systems. One major hindrance with multi-omics, however, is the lengthy and …

Introduction Dental calculus is a mineralized microbial dental plaque biofilm that forms
throughout life by precipitation of salivary calcium salts. Successive cycles of dental plaque …

Despite the crucial roles of lipids in metabolism, we are still at the early stages of comprehensively
annotating lipid species and their genetic basis. Mass spectrometry–based discovery …

Background— Thrombin concentration modulates fibrin structure and fibrin structure
modulates clot stability; however, the impact of localized, cell surface-driven in situ thrombin …