Development of a potent Zika virus vaccine using self-amplifying messenger RNA

K Luisi, KM Morabito, KE Burgomaster, M Sharma… - Science …, 2020 - science.org
Zika virus (ZIKV) is the cause of a pandemic associated with microcephaly in newborns and
Guillain-Barre syndrome in adults. Currently, there are no available treatments or vaccines …

[HTML][HTML] An optimized messenger RNA vaccine candidate protects non-human primates from Zika virus infection

…, H Bennett, S Butler, B Foreman, KE Burgomaster… - npj Vaccines, 2023 - nature.com
Zika virus (ZIKV), an arbovirus transmitted by mosquitoes, was identified as a cause of
congenital disease during a major outbreak in the Americas in 2016. Vaccine design strategies …

[PDF][PDF] A Zika virus-specific IgM elicited in pregnancy exhibits ultrapotent neutralization

…, RJ Edwards, S Valencia, KE Burgomaster… - Cell, 2022 - cell.com
Congenital Zika virus (ZIKV) infection results in neurodevelopmental deficits in up to 14% of
infants born to ZIKV-infected mothers. Neutralizing antibodies are a critical component of …

Broadly neutralizing monoclonal antibodies protect against multiple tick-borne flaviviruses

…, JM Errico, NM Kafai, KE Burgomaster… - Journal of Experimental …, 2021 - rupress.org
Although Powassan virus (POWV) is an emerging tick-transmitted flavivirus that causes severe
or fatal neuroinvasive disease in humans, medical countermeasures have not yet been …

Distinct neutralizing antibody correlates of protection among related Zika virus vaccines identify a role for antibody quality

…, KM Morabito, BM Foreman, KE Burgomaster… - Science translational …, 2020 - science.org
The emergence of Zika virus (ZIKV) in the Americas stimulated the development of multiple
ZIKV vaccine candidates. We previously developed two related DNA vaccine candidates …

Protective efficacy of nucleic acid vaccines against transmission of zika virus during pregnancy in mice

…, P Desai, B Foreman, KE Burgomaster… - The Journal of …, 2019 - academic.oup.com
Zika virus (ZIKV) caused an epidemic of congenital malformations in 2015–2016. Although
many vaccine candidates have been generated, few have demonstrated efficacy against …

DNA vaccination before conception protects Zika virus–exposed pregnant macaques against prolonged viremia and improves fetal outcomes

…, KE Burgomaster, AT Noe, KA Dowd, E Ball… - Science translational …, 2019 - science.org
Zika virus (ZIKV) infection of pregnant women is associated with congenital Zika syndrome (CZS)
and no vaccine is available, although several are being tested in clinical trials. We …

[HTML][HTML] Functional profiling of antibody immune repertoires in convalescent zika virus disease patients

…, KE Burgomaster, KA Dowd, E Normandin… - Frontiers in …, 2021 - frontiersin.org
The re-emergence of Zika virus (ZIKV) caused widespread infections that were linked to
Guillain-Barré syndrome in adults and congenital malformation in fetuses, and epidemiological …

Subcapsular sinus macrophages maximize germinal center development in non-draining lymph nodes during blood-borne viral infection

…, KA Dowd, O Wise-Dent, KE Burgomaster… - Science …, 2024 - science.org
Lymph node (LN) germinal centers (GCs) are critical sites for B cell activation and differentiation.
GCs develop after specialized CD169 + macrophages residing in LN sinuses filter …

A protective human monoclonal antibody targeting the West Nile virus E protein preferentially recognizes mature virions

…, AW Wessel, JM Richner, KE Burgomaster… - Nature …, 2019 - nature.com
West Nile virus (WNV), a member of the Flavivirus genus, is a leading cause of viral encephalitis
in the United States 1 . The development of neutralizing antibodies against the flavivirus …