User profiles for Katherine Hoadley
 | Katherine A. HoadleyUniversity of North Carolina at Chapel Hill Verified email at med.unc.edu Cited by 160784 |
[PDF][PDF] Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
The Cancer Genome Atlas Network recently cataloged recurrent genomic abnormalities in
glioblastoma multiforme (GBM). We describe a robust gene expression-based molecular …
glioblastoma multiforme (GBM). We describe a robust gene expression-based molecular …
[HTML][HTML] The somatic genomic landscape of glioblastoma
…, E Maderna, B Pollo, M Saini, S Balu, KA Hoadley… - cell, 2013 - cell.com
We describe the landscape of somatic genomic alterations based on multidimensional and
comprehensive characterization of more than 500 glioblastoma tumors (GBMs). We identify …
comprehensive characterization of more than 500 glioblastoma tumors (GBMs). We identify …
[PDF][PDF] Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma
We have profiled promoter DNA methylation alterations in 272 glioblastoma tumors in the
context of The Cancer Genome Atlas (TCGA). We found that a distinct subset of samples …
context of The Cancer Genome Atlas (TCGA). We found that a distinct subset of samples …
[PDF][PDF] Genomic classification of cutaneous melanoma
We describe the landscape of genomic alterations in cutaneous melanomas through DNA,
RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 …
RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 …
[PDF][PDF] The molecular taxonomy of primary prostate cancer
There is substantial heterogeneity among primary prostate cancers, evident in the spectrum
of molecular abnormalities and its variable clinical course. As part of The Cancer Genome …
of molecular abnormalities and its variable clinical course. As part of The Cancer Genome …
[PDF][PDF] An integrated TCGA pan-cancer clinical data resource to drive high-quality survival outcome analytics
J Liu, T Lichtenberg, KA Hoadley, LM Poisson… - Cell, 2018 - cell.com
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic
annotation data along with multi-platform molecular profiles of more than 11,000 human tumors …
annotation data along with multi-platform molecular profiles of more than 11,000 human tumors …
[PDF][PDF] Integrated genomic characterization of papillary thyroid carcinoma
Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Here, we
describe the genomic landscape of 496 PTCs. We observed a low frequency of somatic …
describe the genomic landscape of 496 PTCs. We observed a low frequency of somatic …
[PDF][PDF] Comprehensive molecular characterization of muscle-invasive bladder cancer
We report a comprehensive analysis of 412 muscle-invasive bladder cancers characterized
by multiple TCGA analytical platforms. Fifty-eight genes were significantly mutated, and the …
by multiple TCGA analytical platforms. Fifty-eight genes were significantly mutated, and the …
[PDF][PDF] Cell-of-origin patterns dominate the molecular classification of 10,000 tumors from 33 types of cancer
We conducted comprehensive integrative molecular analyses of the complete set of tumors
in The Cancer Genome Atlas (TCGA), consisting of approximately 10,000 specimens and …
in The Cancer Genome Atlas (TCGA), consisting of approximately 10,000 specimens and …
[PDF][PDF] Molecular profiling reveals biologically discrete subsets and pathways of progression in diffuse glioma
Therapy development for adult diffuse glioma is hindered by incomplete knowledge of somatic
glioma driving alterations and suboptimal disease classification. We defined the complete …
glioma driving alterations and suboptimal disease classification. We defined the complete …